Abstract: A rapid and efficient microwave-assisted method for the synthesis of bis(indol-3-yl)methane by the reaction of indoles with aromatic aldehyde catalyzed by Montmorillonite FeCl3 has been developed.The reaction was efficiently performed in the presence of MMT/FeCl3 (x=15%) in CH2Cl2 with high yield up to 94%.The catalyst was reused 4 times and the yield was still up to 60 %.This protocol has the advantages of simple operation,short reaction times,high yields and environmental friendliness,the method is the efficient approach for the synthesis of bis(indol-3-yl)methanes.