N-((pyrrolidin-2-yl)methyl)-1-hydroxynaphthalene-2-carboxamide catalyzed asymmetic Michael addition of anthrone with nitrostyrene

Catalyzed by an organic small molecule N-((pyrrolidin-2-ly)methyl)-1-hydroxynaphthalene-2-carboxamide,asymmetric Michael addition of anthrone with nitrostyrenes has been developed.The reaction was 15 hours efficiently performed in the presence of (15mmol%) at 40℃ in CH2Cl2,obtained in excellent yield (79%~88% yields) and high enantioselectivities (up to 85% ee).The procedure was characterized by lower amount of inexpensive catalyst,mild reaction condition,environmentally benign and simplicity.