Ganoderic acids from the fruiting bodies of Ganoderma resinaceum

Thirteen ganoderic acids were isolated from the 95% ethanol extracts of the fruiting bodies of Ganoderma resinaceum by chromatographic methods including silica gel chromatography, reversed phase chromatography, MCI and Semi-preparative HPLC. The structures of these compounds were elucidated by ¹H NMR and ¹³C NMR techniques. They were identified as resinacein D ( 1 ), leucocontextin I ( 2 ), ganolucidic acid γa ( 3 ), resinacein R ( 4 ), resinacein O ( 5 ), methyl ganoderate C ( 6 ), ganoderic acid AM₁ ( 7 ), ganoderic acid H ( 8 ), 3β,7β-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid ( 9 ), 3β,7β-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester ( 10 ), ganoderense A ( 11 ), resinacein J ( 12 ) and 3β,7β,15β-trihydroxy-8,16-dien-11,23-dioxo-lanost-26-oic acid methyl ester ( 13 ). Compounds 2, 3, 6, 8 , 9 and 11 were isolated from this fungus for the first time.