Current research progress of biaryl chiral compounds

Axial chiral compounds have been widely used in natural products, drug research and development, organic asymmetric catalysis and other fields. In recent years, there are many excellent reports on the related research of axial chiral compounds constructed by two six-membered all-carbon aromatic units as the backbone. In contrast, the asymmetric synthesis of five-membered aromatic heterocyclic biaryl chiral compounds is still immature. This review introduces the major advances in the research of axial chiral biaryl compounds in recent years, and classify a series of representative asymmetric synthesis schemes. On the other hand, we briefly discuss the application value of pyrazole biaryl chiral compounds in various fields and the difficulties and challenges encountered in asymmetric synthesis, and introduce several excellent synthesis schemes, and comprehensively discuss the current research situation.