Quantitative structure-activity relationships(QSAR) of 2-phenylindole derivatives

The geometry structure of 36 2-phenylindole derivatives were optimized by AM1.The parameters of the electronic,geometric and topological structures,such as net charge,dihedral,bond length and topological index,were obtained by the technique of molecule graphics and AM1.The correlations among the structures and affinities of 36 2-phenylindole derivatives for the estrogen receptor in calf uterus sere done with QSAR.The results from the correlations were satisfactory.