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LIU Jin, YANG Li-rong, LI Hong-hong, ZHU Hong-you, LIU Fu-chu. Improved synthesis of IPL576,092:a novel anti-asthma agentJ. Journal of Yunnan University: Natural Sciences Edition, 2009, 31(2): 183-186 .
Citation: LIU Jin, YANG Li-rong, LI Hong-hong, ZHU Hong-you, LIU Fu-chu. Improved synthesis of IPL576,092:a novel anti-asthma agentJ. Journal of Yunnan University: Natural Sciences Edition, 2009, 31(2): 183-186 .
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Improved synthesis of IPL576,092:a novel anti-asthma agent

    Abstract
  • An improved synthesis of IPL576,092 has been accomplished starting from the commercially availabbe DHEA(dehydroisoandrosterone) in six steps in 27% overall yields.The procedure involves the selective allyic oxidation of 5-androsten-3β-ol-17-one ethylene ketal by NHPI/O2/Bz2O2-CuCl2 system and the hydroboration of 5-androsten-7,17-dione-3β-ol 17-ethylene ketal by BF3·OEt2/NaBH4-NaBO3 system as key steps.Workup procedures were simplified.
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