Abstract:
Eighteen kinds of types HPV E7 protein were analyzed by bioinformatics.Meanwhile,we predicted HPV58 type structure and binding site.We obtained protein sequences from NCBI database,analyzeed biological information by using ExPASy Protparam tool,carried out multiple sequence alignment,constructed phylogenetic tree by MEGA software.And we predicted protein structure and the binding site of HPV58 E7 by Zhang lab Quark software and Q-SiteFinder which is energy-based site detection.We got the biological information,multiple sequence alignment,phylogenetic tree of E7 protein.We also obtained the structure of HPV58 E7 and found the possible binding site of HPV58 E7.There exists evolution difference in high-risk HPVE7 protein.The structure and possible site provide related theory for inhibiting the function of E7 by binding E7 protein.