Abstract: In this paper,hollow cystic silver-palladium-platinum composite nanomaterials was synthesized and used as label to construct carcinoembryonic antigen(CEA) immunesensor for rapid detection of CEA.Firstly,CEA antibody(anti-CEA) is fixed at a gold electrode surface by using Au-SH bonding,combined with the CEA antigen immunization,and then bonded with silver- palladium-platinum nanocomposite labeled anti-CEA,in this way sandwich-type immune sensor was prepared.The features of electrochemical properties were examined.Cultivation time and concentration of antibody immobilized,and other experimental conditions affected the performance of the sensor were optimized.The sensor has good linearity with concentration of CEA antigen from 0.1 ng/mL to 40 ng/mL with detection limit of 0.03 ng/mL.Experimental results show that the sensor is easy to operate with high sensitivity and selectivity,good reproducibility and stability.