何江波, 李兆桥, 贾静, 陶剑, 张雪梅, 缪希松, 何方, 句红萍. 海洋来源普通青霉菌(Penicillium commune 366606)的化学成分研究[J]. 云南大学学报(自然科学版), 2015, 37(4): 564-568. doi: 10.7540/j.ynu.20150160
引用本文: 何江波, 李兆桥, 贾静, 陶剑, 张雪梅, 缪希松, 何方, 句红萍. 海洋来源普通青霉菌(Penicillium commune 366606)的化学成分研究[J]. 云南大学学报(自然科学版), 2015, 37(4): 564-568. doi: 10.7540/j.ynu.20150160
HE Jiang-bo, LI Zhao-qiao, JIA Jing, TAO Jian, ZHANG Xue-mei, MIAO Xi-song, HE Fang, JU Hong-ping. Study on the chemical constituents of Penicillium commune 366606 from marine fungus[J]. Journal of Yunnan University: Natural Sciences Edition, 2015, 37(4): 564-568. DOI: 10.7540/j.ynu.20150160
Citation: HE Jiang-bo, LI Zhao-qiao, JIA Jing, TAO Jian, ZHANG Xue-mei, MIAO Xi-song, HE Fang, JU Hong-ping. Study on the chemical constituents of Penicillium commune 366606 from marine fungus[J]. Journal of Yunnan University: Natural Sciences Edition, 2015, 37(4): 564-568. DOI: 10.7540/j.ynu.20150160

海洋来源普通青霉菌(Penicillium commune 366606)的化学成分研究

Study on the chemical constituents of Penicillium commune 366606 from marine fungus

  • 摘要: 研究海洋来源普通青霉菌Penicillium commune 366606的化学成分.人工海水发酵,发酵产物通过乙酸乙酯萃取后得浸膏,运用硅胶柱色谱、凝胶柱色谱(Sephadex LH-20)和反相RP-18柱色谱进行分离纯化.运用现代波谱学方法(NMR、MS)和结合文献数据等对分离所得化合物的结构进行鉴定.从海洋真菌发酵液中分离得到7个化合物,结构分别鉴定为melithasterol B(1)、chrysophanol(2)、2’,3’-dihydrosorbicllin(3)、2-pyruvoybenzamide(4)、2-aceylquinazolin-4(3H)-one(5)、fenestins A(6)、cyclo(D-Pro-D-Leu)(7).所有化合物均为首次从普通青霉菌(Penicillium commune 366606)中分离得到,并报道了化合物4~7对5株癌细胞活性研究.

     

    Abstract: The chemical constituents of Penicillium commune 366606 were studied.The compounds were isolated by silica column chromatography,Sephadex LH-20 column chromatography and RP-18 reverse-phase column chromatography respectively.The structures were elucidated on the basis of spectral characteristics and compared with the data of literatures.From the ethyl acetate extracts of Penicillium commune 366606,seven compounds were isolated and identified as melithasterol B (1),chrysophanol (2),2,3-dihydrosorbicllin (3),2-pyruvoybenzamide (4),2-aceylquinazolin-4(3H)-one (5),fenestins A (6),cyclo(D-Pro-D-Leu) (7).All compounds were obtained from Penicillium commune 366606 for the first time.Compounds 4—7 showed inactive against K562,A549,HL-60,SMMC-7721,MCF-7 and SW-480.

     

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