Abstract:
The chemical constituents of Penicillium commune 366606 were studied.The compounds were isolated by silica column chromatography,Sephadex LH-20 column chromatography and RP-18 reverse-phase column chromatography respectively.The structures were elucidated on the basis of spectral characteristics and compared with the data of literatures.From the ethyl acetate extracts of Penicillium commune 366606,seven compounds were isolated and identified as melithasterol B (1),chrysophanol (2),2,3-dihydrosorbicllin (3),2-pyruvoybenzamide (4),2-aceylquinazolin-4(3H)-one (5),fenestins A (6),cyclo(D-Pro-D-Leu) (7).All compounds were obtained from Penicillium commune 366606 for the first time.Compounds 4—7 showed inactive against K562,A549,HL-60,SMMC-7721,MCF-7 and SW-480.