付旭锋, 刘平, 陈冰冰, 焦扬, 司维, 郑冰蓉. 间充质干细胞冻存方法的研究进展[J]. 云南大学学报(自然科学版), 2016, 38(4): 652-660. doi: 10.7540/j.ynu.20160104
引用本文: 付旭锋, 刘平, 陈冰冰, 焦扬, 司维, 郑冰蓉. 间充质干细胞冻存方法的研究进展[J]. 云南大学学报(自然科学版), 2016, 38(4): 652-660. doi: 10.7540/j.ynu.20160104
FU Xu-feng, LIU Ping, CHEN Bing-bing, JIAO Yang, SI Wei, ZHENG Bing-rong. Review of the progress on the cryopreservation methods of mesenchymal stem cells[J]. Journal of Yunnan University: Natural Sciences Edition, 2016, 38(4): 652-660. DOI: 10.7540/j.ynu.20160104
Citation: FU Xu-feng, LIU Ping, CHEN Bing-bing, JIAO Yang, SI Wei, ZHENG Bing-rong. Review of the progress on the cryopreservation methods of mesenchymal stem cells[J]. Journal of Yunnan University: Natural Sciences Edition, 2016, 38(4): 652-660. DOI: 10.7540/j.ynu.20160104

间充质干细胞冻存方法的研究进展

Review of the progress on the cryopreservation methods of mesenchymal stem cells

  • 摘要: 间充质干细胞(mesenchymal stem cells,MSCs)是具有自我复制能力和多向分化潜能的成体干细胞,它能够发育成硬骨、软骨、脂肪和其他类型的细胞,因此已成为细胞治疗的重要候选种子细胞,特别在各种退行性疾病和自身免疫性疾病的组织修复和免疫调节方面有良好的应用前景.有效的应用须建立在有生物学特性保持良好的充足MSCs的前提下.由于临床上细胞移植的供体和受体往往存在不同时性,很难保证即离即用,且充足的数量需求保证也会是一个问题.因此,能保证良好生物学特性稳定保持的MSCs冻存方法就显得尤为重要.本文即对MSCs冻存技术的研究进展进行综述.

     

    Abstract: Mesenchymal stem cells (MSCs), a population of adult stem cells,are defined by their capacity of self- replicating and differentiation into bones,cartilages,adipose tissues and some other types of cells,which depends on certain stimuli and culture conditions.It has been proved that MSCs have become important candidate cells in cell therapy,especially for tissue repair and immune regulation in degenerative diseases and autoimmunity diseases.As getting high quality MSCs is the base of its clinic application,it is especially important to establish an effective method on cryopreservation.This review is just focus on the developments in cryopreservation of MSCs.

     

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