Abstract: This paper introduces a kind of phonocardiogram signal acquisition system based on FPGA.This system includes a phonocardiogram signal sensor and acquisition circuit,and the low-power audio codec WM8731 chip with an integrated headphone driver.Phonocardiogram sensor works by converting the phonocardiogram signal into electrical signals and transmitting into the signal acquisition board.After amplification and filtration,the signal is further transmitted to WM8731 chip which on FPGA through A/D conversion,and is finally received by RS232 serial port of PC.This design shows that the system can meet the requirements for rapid collection of phonocardiogram signal,laying solid foundation for the subsequent signal processing.