崔时胜, 罗大云, 林军, 严胜骄. 2-氰基-2-(1,3-二烷基咪唑烷-2-亚基)乙酸乙酯衍生物的合成[J]. 云南大学学报(自然科学版), 2017, 39(1): 120-123. doi: 10.7540/j.ynu.20160378
引用本文: 崔时胜, 罗大云, 林军, 严胜骄. 2-氰基-2-(1,3-二烷基咪唑烷-2-亚基)乙酸乙酯衍生物的合成[J]. 云南大学学报(自然科学版), 2017, 39(1): 120-123. doi: 10.7540/j.ynu.20160378
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CUI Shi-sheng, LUO Da-yun, LIN Jun, YAN Sheng-jiao. Synthesis of ethyl 2-cyano-2-(1,3-dialkylimidazolidin-2-ylidene)-acetate derivatives[J]. Journal of Yunnan University: Natural Sciences Edition, 2017, 39(1): 120-123. DOI: 10.7540/j.ynu.20160378
Citation: CUI Shi-sheng, LUO Da-yun, LIN Jun, YAN Sheng-jiao. Synthesis of ethyl 2-cyano-2-(1,3-dialkylimidazolidin-2-ylidene)-acetate derivatives[J]. Journal of Yunnan University: Natural Sciences Edition, 2017, 39(1): 120-123. DOI: 10.7540/j.ynu.20160378
shu

2-氰基-2-(1,3-二烷基咪唑烷-2-亚基)乙酸乙酯衍生物的合成

Synthesis of ethyl 2-cyano-2-(1,3-dialkylimidazolidin-2-ylidene)-acetate derivatives

    摘要
  • 摘要: 建立了以DMF为介质,氢化钠为碱,室温条件下,双取代杂环烯酮缩胺1与卤代化合物2反应,一步合成2-氰基-2-(1,3-二烷基咪唑烷-2-亚基)乙酸乙酯衍生物3的方法.该反应具有操作简便、条件温和、产率高 (87%~93%) 等特点.

     

    Abstract: The protocol for ethyl 2-cyano-2-(1,3-dialkylimidazolidin-2-ylidene)acetate derivatives 3 via one step reaction between bis-substituted heterocyclic ketene aminals (HKAs) 1 and halogen compounds 2 in DMF medium at room temperature and sodium hydride as alkali has been developed.This reaction has the advantages such as operational simplicity,mild reaction conditions and excellent yields (87%—93%).

     

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