MMT/FeCl3催化的2-二乙硫基亚甲基-3-羟基丁酸乙酯与吲哚衍生物的Friedel-Crafts烷基化反应
MMT/FeCl3-catalyzed Friedel-Crafts Alkylation of Ethyl 2-(bis(ethylthio)methylene)-3-hydroxybutanoate with Indole Derivatives
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摘要: 探讨了价廉易得、环境友好和无毒性的MMT/FeCl3催化的α-羟基二硫缩烯酮与吲哚衍生物的Friedel-Crafts烷基化反应.研究表明,在室温条件下,CH2Cl2中,在x=15% MMT/FeCl3存在下,α-羟基二硫缩烯酮与吲哚衍生物能有效进行Friedel-Crafts烷基化反应,高产率生成α-吲哚基二硫缩烯酮.反应具有催化剂经济易得及其用量少、反应条件温和、环境友好和易操作等优点.Abstract: An inexpensive and environmentally friendly MMT/FeCl3 catalyzed Friedel-Crafts alkylation of α-hydroxy ketene dithioacetals with indole derivatives has been developed.The reaction was efficiently performed in the presence of MMT/FeCl3(15mol%) at room temperature in CH2Cl2,affording α-indolyl ketene dithioacetals in excellent yields.The procedure was characterized by lower amount of inexpensive catalyst,mild reaction condition,environmentally benign and simplicity.
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