Abstract: In recent years,studies have shown that Se4+ could reduce the pollution of heavy metal.In this study,root length,seeding height,root activity,superoxide dismufase (SOD),catalase(CAT) and malondialdehyde(MDA) were investigated at seedling stage of two wheat cultivars (Shumai969 and Chuannong16) which were stressed by Hg2+,Cd2+ and Pb2+ with different ρ(Se4+) treatment.The results showed that root length,seedling height,root activity,SOD,CAT and MDA were affected by Hg2+,Cd2+ and Pb2+ treatments,and adding ρ(Se4+) at 5mg·L-1 reduced the effect of pollution.While increasing Se4+ to 15mg/L,the stress by the heavy metals was aggravated.It is concluded that ρ(Se4+) could alleviate heavy metal pollution under proper concentration which varies by genotypes,providing theoretical basis for solving heavy metal pollution in wheat growing areas.