林婷婷, 李铭刚, 丁章贵, 文孟良, 张洪彬, 赵江源. 昆明盐矿真菌次生代谢产物的分离与鉴定[J]. 云南大学学报(自然科学版), 2017, 39(6): 1065-1072. doi: 10.7540/j.ynu.20170192
引用本文: 林婷婷, 李铭刚, 丁章贵, 文孟良, 张洪彬, 赵江源. 昆明盐矿真菌次生代谢产物的分离与鉴定[J]. 云南大学学报(自然科学版), 2017, 39(6): 1065-1072. doi: 10.7540/j.ynu.20170192
LIN Ting-ting, LIming-gang, DING Zhang-gui, WEN Meng-liang, ZHANG Hong-bin, ZHAO Jiang-yuan. Secondary metabolites from cultures of halotolerant fungal from Kunming Salt Mine[J]. Journal of Yunnan University: Natural Sciences Edition, 2017, 39(6): 1065-1072. DOI: 10.7540/j.ynu.20170192
Citation: LIN Ting-ting, LIming-gang, DING Zhang-gui, WEN Meng-liang, ZHANG Hong-bin, ZHAO Jiang-yuan. Secondary metabolites from cultures of halotolerant fungal from Kunming Salt Mine[J]. Journal of Yunnan University: Natural Sciences Edition, 2017, 39(6): 1065-1072. DOI: 10.7540/j.ynu.20170192

昆明盐矿真菌次生代谢产物的分离与鉴定

Secondary metabolites from cultures of halotolerant fungal from Kunming Salt Mine

  • 摘要: 对昆明盐矿真菌4-92的次生代谢产物进行了化学成分研究,从中分离得到15个化合物.通过波谱数据分析,鉴定其结构分别为5个酚类化合物:5-甲苯-1,3-二醇(1)、甲基 2,5-龙胆酸(2)、对羟基苯甲酸(3)、3,3'-氧二苯(5-甲酚) (4)、2-(羟甲基)苯-1,4-苯二酚(5);3个甾醇类化合物: (22E,24R)-5,6-环氧-24-甲基胆甾-8(14),22-烯-3,7-二醇(6)、3-羟基-(22E,24R)-麦角甾-5,8,22-三烯-7-酮(7)、啤酒甾醇(8);3个核苷类化合物:胸腺嘧啶(9)、尿嘧啶(10)、胞嘧啶(11);2个氧杂蒽酮类化合物:杂色黄曲霉毒素(12)、Oxisterigmatocystin C(13);一个蒽醌类化合物:大黄素(14);一个生物碱类化合物:Pseurotin A(15).

     

    Abstract: The chemical constituents from the liquid fermentation of halotolerant fungal 4-92 from Kunming Salt Mine were studied.Fifteen compounds were isolated,and their structures were determined by spectral analysis as five phenolic compounds:5-methyl-benzene-1,3-diol(1),methyl 2,5-dihydroxybenzoate(2),4-hydroxybenzoic acid(3),3,3'-oxybis(5-methylphenol) (4),2-(hydroxymethyl)benzene-1,4-diol(5);three sterol compounds (22E,24R)-5,6-epoxy-24-methylcholesta-8(14),22-diene-3,7-diol(6),3-hyd-roxy-(22E,24R)-ergosta-5,8,22-trien-7-one(7),(22E,24R)-24-methylcholesta-7,22-diene-3,5,6-tiol(8); three nucleoside compounds thymine(9),uracil(10),cytosine(11);two xanthone compounds sterigmatocystin(12),oxisterigmatocystin C(13);an anthraquinone compound:emodin(14)and an alkaloid compound:Pseurotin A(15).

     

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