Abstract: The 2-amino-3,5-dicyano-4,6-diphenyl-4H-pyran derivatives were synthesized by one-pot method using DMAP as catalyst, aromatic aldehyde, benzoylacetonitrile and malononitrile as raw materials and ethanol as solvent.The effects of catalyst dosage, reaction time, reaction temperature, molar ratio of raw materials on yield were investigated. The results showed that the optimum process conditions for the synthesis of this compound were as follows: the catalyst dosage was 10 mol% of benzoylacetonitrile, The mole ratio of aromatic aldehyde to benzoylacetonitrile and malononitrile was 1.1∶1.0∶1.1.The yields range from 89.9 % to 98.5%. This methodology provides one convenient and high efficient approach to the 2-amino-3,5-dicyano-4,6-diphenyl-4H-pyran derivatives library.