魏可可, 罗建萍, 季四平, 陈海云, 杨丽娟, 钏永明. 固载硫脲催化剂的合成及不对称Mannich反应的应用[J]. 云南大学学报(自然科学版), 2019, 41(1): 151-156. doi: 10.7540/j.ynu.20180422
引用本文: 魏可可, 罗建萍, 季四平, 陈海云, 杨丽娟, 钏永明. 固载硫脲催化剂的合成及不对称Mannich反应的应用[J]. 云南大学学报(自然科学版), 2019, 41(1): 151-156. doi: 10.7540/j.ynu.20180422
shu
WEI Ke-ke, LUO Jian-ping, JI Si-ping, CHEN Hai-yun, YANG LI-juan, CHUAN Yong-ming. Synthesis of immobilized thiourea catalyst and application of asymmetric Mannich reaction[J]. Journal of Yunnan University: Natural Sciences Edition, 2019, 41(1): 151-156. DOI: 10.7540/j.ynu.20180422
Citation: WEI Ke-ke, LUO Jian-ping, JI Si-ping, CHEN Hai-yun, YANG LI-juan, CHUAN Yong-ming. Synthesis of immobilized thiourea catalyst and application of asymmetric Mannich reaction[J]. Journal of Yunnan University: Natural Sciences Edition, 2019, 41(1): 151-156. DOI: 10.7540/j.ynu.20180422
shu

固载硫脲催化剂的合成及不对称Mannich反应的应用

Synthesis of immobilized thiourea catalyst and application of asymmetric Mannich reaction

    摘要
  • 摘要: 以N-Boc(2S, 4S)-4-甲磺酰氧基吡咯-2-甲酸甲酯为原料，合成了固载的含有硫脲官能团的双功能有机催化剂C，并将其用于催化异戊醛与N-PMP乙醛酸乙酯亚胺的不对称anti-Mannich反应，通过初步的条件筛选，获得了高的收率(83%)和高选择性(dr: 96:4；ee: anti 90%).

     

    Abstract: The immobilized bifunctional organic catalyst C containing thiourea functional group was synthesized from N-Boc(2S, 4S)-4-methanesulfonyloxypyrrole-2-carboxylic acid methyl ester as a raw material, and applied to catalyze asymmetric anti-Mannich reaction of valeraldehyde with N-PMP ethyl glyoxyimide. High yield (83%) and high selectivity (dr: 96:4; ee: 90%) obtained by preliminary conditions screening.

     

    • HTML全文
    • 参考文献(22)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回