刘文星, 邱仕瑜, 陈毅坚, 董淼, 周敏. 无柄灵芝子实体中的灵芝酸类化合物[J]. 云南大学学报(自然科学版), 2020, 42(3): 553-559. doi: 10.7540/j.ynu.20190525
引用本文: 刘文星, 邱仕瑜, 陈毅坚, 董淼, 周敏. 无柄灵芝子实体中的灵芝酸类化合物[J]. 云南大学学报(自然科学版), 2020, 42(3): 553-559. doi: 10.7540/j.ynu.20190525
LIU Wen-xing, QIU Shi-yu, CHEN Yi-jian, DONG Miao, ZHOU Min. Ganoderic acids from the fruiting bodies of Ganoderma resinaceum[J]. Journal of Yunnan University: Natural Sciences Edition, 2020, 42(3): 553-559. DOI: 10.7540/j.ynu.20190525
Citation: LIU Wen-xing, QIU Shi-yu, CHEN Yi-jian, DONG Miao, ZHOU Min. Ganoderic acids from the fruiting bodies of Ganoderma resinaceum[J]. Journal of Yunnan University: Natural Sciences Edition, 2020, 42(3): 553-559. DOI: 10.7540/j.ynu.20190525

无柄灵芝子实体中的灵芝酸类化合物

Ganoderic acids from the fruiting bodies of Ganoderma resinaceum

  • 摘要: 对无柄灵芝Ganoderma resinaceum子实体进行了化学成分研究,该大型真菌经过95%乙醇提取后,再使用正相柱色谱、反相柱色谱、MCI柱色谱以及半制备HPLC等技术手段分离得到了13个灵芝酸类化合物. 这些化合物的结构通过核磁共振技术(1H NMR、13C NMR)得到了鉴定,它们分别为resinacein D( 1 )、leucocontextin I( 2 )、ganolucidic acid γa( 3 )、resinacein R( 4 )、resinacein O( 5 )、甲基灵芝酸C( 6 )、灵芝酸AM17 )、灵芝酸H( 8 )、3β,7β-二羟基-11,15,23-三羰基-羊毛甾烷-8,16-二烯-26-羧酸( 9 )、3β,7β-二羟基-11,15,23-三羰基-羊毛甾烷-8,16-二烯-26-羧酸甲酯( 10 )、ganoderense A( 11 )、resinacein J( 12 )以及3β,7β,15β-三羟基-8,16-二烯-11,23-二羰基-羊毛甾烷-26-羧酸甲酯( 13 ),其中化合物2、3、6、8、9和化合物11为首次从该大型真菌中分离得到.

     

    Abstract: Thirteen ganoderic acids were isolated from the 95% ethanol extracts of the fruiting bodies of Ganoderma resinaceum by chromatographic methods including silica gel chromatography, reversed phase chromatography, MCI and Semi-preparative HPLC. The structures of these compounds were elucidated by 1H NMR and 13C NMR techniques. They were identified as resinacein D ( 1 ), leucocontextin I ( 2 ), ganolucidic acid γa ( 3 ), resinacein R ( 4 ), resinacein O ( 5 ), methyl ganoderate C ( 6 ), ganoderic acid AM1 ( 7 ), ganoderic acid H ( 8 ), ,7β-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid ( 9 ), 3β,7β-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid methyl ester ( 10 ), ganoderense A ( 11 ), resinacein J ( 12 ) and 3β,7β,15β-trihydroxy-8,16-dien-11,23-dioxo-lanost-26-oic acid methyl ester ( 13 ). Compounds 2, 3, 6, 8 , 9 and 11 were isolated from this fungus for the first time.

     

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