海藻酸钠/壳聚糖缓释微球的制备及性能
Preparation and property of alginate/chitosan microspheres for controlled releasing
-
摘要: 利用海藻酸钠(SA)聚阴离子及壳聚糖(CS)聚阳离子电解质的性质,以顺铂(DDP)为模型药,采用乳化交联法制备海藻酸钠-DDP缓释微球,根据静电吸附原理合成SA/DDP/CS复合载药微球.研究微球对药物分子的包载能力及释药特性.结果显示,制备的微球圆整,载药微球表面致密且分散性好,微球粒径在11.0~58.8μm之间,采用原子吸收分光光度计对载药微球的载药率、药物包封率和药物体外释放性质进行了测试和分析,结果表明载药微球缓释效果明显,减少了药物的投放量和投放次数,降低了毒副作用.Abstract: Alginate (SA) and Chitosan (CS) were anion and cation polyelectrolyte,respectively. Using cis-Diamminedichloroplatinum (DDP) as the model drug, microspheres loaded with DDPwere prepared by crosslinking-emulsion method.Electrostatic absorption technique was used to prepare DDPmicrospheres coated with CS.The drug loaded in SA/CS/DDP microspheres was observed by SEM,and the results indicated that these microspheres showed dense surface and excellent sphere-forming ability, and the sizes of microspheres are in the range of 11.0—58.8μm.In addition,the drug loading ratio and efficiency as well as drug releasing curves were also investigated in vitro,and the results showed that SA/DDP/CSmicrospheres displayed an excellent drug controlled releasing.