李大雄, 龙晶, 林海娇, 李聪, 郑永唐, 何严萍. 6-(1H-吲哚-3-甲基)- 5-乙基-3H-嘧啶-4-酮类化合物的合成及抗HIV活性研究[J]. 云南大学学报(自然科学版), 2010, 32(5): 572-576, .
引用本文: 李大雄, 龙晶, 林海娇, 李聪, 郑永唐, 何严萍. 6-(1H-吲哚-3-甲基)- 5-乙基-3H-嘧啶-4-酮类化合物的合成及抗HIV活性研究[J]. 云南大学学报(自然科学版), 2010, 32(5): 572-576, .
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Synthesis and Anti-HIV Activity of 6-((1H-indol -3-yl)methyl) -5-ethyl-pyrimidin-4(3H)-one Analogues[J]. Journal of Yunnan University: Natural Sciences Edition, 2010, 32(5): 572-576, .
Citation: Synthesis and Anti-HIV Activity of 6-((1H-indol -3-yl)methyl) -5-ethyl-pyrimidin-4(3H)-one Analogues[J]. Journal of Yunnan University: Natural Sciences Edition, 2010, 32(5): 572-576, .
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6-(1H-吲哚-3-甲基)- 5-乙基-3H-嘧啶-4-酮类化合物的合成及抗HIV活性研究

Synthesis and Anti-HIV Activity of 6-((1H-indol -3-yl)methyl) -5-ethyl-pyrimidin-4(3H)-one Analogues

    摘要
  • 摘要: 基于二氢烷氧苄基嘧啶酮(DABO)类非核苷类逆转录酶抑制剂(NNRTIs)的构效关系研究,设计合成了2个新的6-(1H-吲哚-3-甲基)- 5-乙基-3H-嘧啶-4-酮类化合物,并采用C8166细胞进行了体外抗HIV活性测试,为新型S-DABO类非核苷类逆转录酶抑制剂结构修饰提出了新的设想.

     

    Abstract: Based on the research of structure-activity relationship(SAR) of dihydro- alkoxy-benzyl-oxopyrimidine(DABO) analogue as non-nucleoside reverse transcriptase inhibitors(NNRTIs),two novel 6-((1H-indol-3-yl)methyl)-5-ethyl-pyrimidin-4(3H)-one analogues were designed,synthesized and evaluated in vitro anti-HIV activity in C8166 cell.The results provided new idea for further rational design of new S-DABO derivatives as NNRTIs

     

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