Abstract: Extract the annual anomaly characteristics of water level by analyzing the annual rainfall and next year's water level changes of valley values in area of 11 observation wells which appears significant low level in eastern Yunnan.We found that it has a good corresponding relationship between the abnormal well ratio in anomalous year and the M6.0 earthquake in current year and next year,it will occure M6.0 earthquake in eastern Yunnan and the surrounding areas when the abnormal well ratio beyond the normal dynamic range above 0.27 since 2002,the corresponding rate is 80% (4/5).It can be predict and estimate the annual maximum seismic activity level and seismic intensity by using this method.