Abstract: Regional metallogenic evolution mainly controlled by regional tectonic evolution is one of important contents in the research of metallogenic regularities.Based on the relationship between regional tectonic evolution-metallogenic systems in Lanping-Simao area,we pointed out that three stages of tectonic evolution were experienced in the district since early Palaeozoic:Proto-Tethys to Paleo-Tethys opened-closed and interacted with multipe land mass stage(Pz1-T2),New-Tethys opened and basin formed stage(T3-K),continent-continent collision orogeny and basin-range structure forming stage(E-Q).At same time,we also pointed that the process of Cu-polymetallic metallogenic evolution in the district mainly included volcanic exhalative-sedimentary mineralization in back-arc rift(S)exhalative-sedimentary mineralization in ocean basin(Pz2)mantle-derived magma( or Cu-Ni sulfide) mineralization in subduction collision belt(P) volcanic hydrothermal-sedimentary mineralization in island arc(P-T2) exhalative-sedimentary mineralization in foreland basinthermal brine mineralization in the red-bed basin(J-E).Among them,marine volcanic exhalative-sedimentary，Cu-Ni sulfide and transformed deposits were important metallogeneic types.