Abstract: In this paper,a mathematic model for the optimal control system of water flooding station in oil field is established,which uses maximizing systematic efficiency of water flooding station as objective function and water flooding flux,pressure and flux of water flooding Pump and so on as the parameters of stipulation,then uses real-time collected data and product data as boundary condition,and the optimal control system is designed.at last,the computer simulation experiment has been completed.By this simulation model,the real-time working parameters of the system in water flooding station can be calculated optimally.The correction of mathematic model and Matlab simulation model is validated with calculating practical data of the Huatugou and the Shizigou water flooding station in the west of Qaidam Basin.