宋霞, 段维国, 全文琦, 黄铠, 张晓丽, 张云昆, 谢明学, 谢忠平. OPV疫苗液体剂型稳定性影响因素分析[J]. 云南大学学报(自然科学版), 2008, 30(1): 98-100,108.
引用本文: 宋霞, 段维国, 全文琦, 黄铠, 张晓丽, 张云昆, 谢明学, 谢忠平. OPV疫苗液体剂型稳定性影响因素分析[J]. 云南大学学报(自然科学版), 2008, 30(1): 98-100,108.
SONG Xia, DUAN Wei-guo, QUAN Wen-qi, HUANG Kai, ZHANG Xiao-li, ZHANG Yun-kun, XIE Min-xue, XIE Zhong-ping. Stabilities of live attenuated oral poliomyelitis vaccine[J]. Journal of Yunnan University: Natural Sciences Edition, 2008, 30(1): 98-100,108.
Citation: SONG Xia, DUAN Wei-guo, QUAN Wen-qi, HUANG Kai, ZHANG Xiao-li, ZHANG Yun-kun, XIE Min-xue, XIE Zhong-ping. Stabilities of live attenuated oral poliomyelitis vaccine[J]. Journal of Yunnan University: Natural Sciences Edition, 2008, 30(1): 98-100,108.

OPV疫苗液体剂型稳定性影响因素分析

Stabilities of live attenuated oral poliomyelitis vaccine

  • 摘要: 分析了温度、反复冻融、冷链运输过程对口服脊髓灰质炎减毒活疫苗(OPV)滴度的影响,检测结果显示OPV分别在37℃条件下放置3d,25℃放置14d,-20℃放置36个月、反复冻化35次,感染性滴度均无明显变化.在冷链条件下运输,其感染性滴度无明显变化.液体剂型的稳定性优于糖丸剂型(t=3.2043,P0.01).

     

    Abstract: The influences of temperature,freezing and melting repeatedly and cold-chain transportation on oral polio vaccine(OPV) were analyzed.The results indicated that the titers of OPV had no obvious changes after being put at 37 ℃ for 3 days,25 ℃ for 14 days and-20℃ for 36 months,and being freezed and melted for 35 times,respectively.The titers had no obvious changes under the cold-chain transportation.The stability of the liquid form is better than the dragee candy form(t=3.204 3,P0.01).

     

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