三分子(叠氮化钠、炔烃、乙酸酯)反应合成1,4-二取代-1,2,3-三氮唑

Three-molecule (sodium azide,alkynes and acetic ester)reaction synthesised of 1,4-disubstituted 1,2,3-triazoles

摘要: 用三分子反应合成了1,4-二取代-1,2,3-三氮唑.碘化亚铜催化叠氮化钠、炔烃、乙酸酯三分子反应合成1,4-二取代-1,2,3-三氮唑,产率82%~92%。在该点击化学过程中无需直接使用有机叠氮化物,整个点击过程环境友好、安全、产率高.

Abstract: Triazole is an important organic compound.In this article,we synthesised 1,4-disubstituted-1,2,3-triazoles with three molecule reaction.A three-molecule reaction was used to prepare a series of 1,4-disubstituted -1,2,3-triazoles from corresponding sodium azide,alkynes and acetic ester via CuI catalyst,with a yield of 82%—92%.This click process eliminates the need to handle organic azides and make this process even more friendly,safe and high efficiency.