Abstract: Using MSR global total ozone data,spatial-temporal change of global total ozone from 1978 to 2008 have been constructed.The results are as follows:① the global even total ozone has observably reduced before 1996,and descendent trend has diminished after that.The regression coefficient was -1.037 4×10-4cm/month before March 1996,it was -3.750 0×10-6cm/month after that.② The total ozone has generally decreased in global before 1996,and remarkable descendent region has appeared in middle latitude of the Northern Hemisphere and middle-high latitude of the Southern Hemisphere.Since 1996,large-scale total ozone increased region was found between 60°S—30°N and the north of North America and the east sea area.But the increased and decreased amounts were tiny.③ Ozone change status was different in diverse regions.The total ozone has consistent reduced,then slightly increased over the Tibetan Plateau.It has almost steadied at the first time,and then increased in West Pacific Ocean.It has experienced the change of sharp reduced-slightly increased over South Pole.