Abstract: We provided a method that extracting translating and rotating information from X-rays film of patient based on transversal and longitudinal inferences,then we used the method and standard 3D spine model to reconstruct the space structure of lesion spine,that can make the doctors view the patient’s spine from multi-perspective.We also proposed a new computer-aided measurement method for Cobb angle measurement,and analyzed the feasibility of this method.Final,we tested our 3D reconstruction algorithm base on Marching Cubes and the 3D information combination,the results proved that the algorithm has the advantages of simple calculation,high efficiency and realizability,and it can accurately simulate spinal space construction of patients.