Abstract: The permeability is one of the most important properties of microcapsules.It is reported a modification for alginate-chitosan microcapsules with nanosized gold citrate or acrylate.The comparison of permeabilities for gold-alginate-chitosan microcapsules modified with nanosized gold citrate and acrylate was reported by spectrophotometry and using Vitamin B12 as penetrant.The experimental results showsed that the permeability of gold-alginate-chiosan microcapsules treated with citrate was higher than that of gold-alginate-chitosan microcapsules treated with acrylate.