Abstract: The qualitative antibacterial activities of two new inorganic antibacterial agents TiO2 and ZnO were studied to the typical Gram-negative bacteria,Gram-positive bacteria,bacillus,microzyme and mould by the experiments of vibrating flask and the disk diffusion.The experimental results show that the two new nanometer inorganic antibacterial agents have broad-spectrum antibacterial activities and the antibacterial effect is much better than that of organic antibacterial agents and the inorganic antibacterial agents mend in Japan.Moreover,the antibacterial mechanism of the correlative antibacterial agents has been discussed.