Abstract: HSVECs angiogenesis model was first developed and compared with HUVECs angiogenesis model.HSVECs and HUVECs were separately sandwiched into the 3-D collagen gels to culture the angio-genesis model in vitro;the anti-angiogenic effects of genistein was assessed in this system.HSVECs have the capacity to form capillary-like structures in this model,the organization process was slower than HUVECs angiogenesis model.This new HSVEC angiogenesis model has been proved to be as a anti-angiogenic screening model.