Abstract: Using the technology of high temperature-high strain rate coupling split Hopkinson bar and universal testing machine controlled by computer of 100KN,the mechanical experiment under the condition of high strain-rate loading on cylindrical sample and hat-shape sample of TC6 titanium alloy with equiaxed structure have been conducted and its mechanical behavior and fracture failure have been investigated.It is showed that the TC6 titanium alloy with equiaxed structure take on the effect of strain-strengthening at quasi-static deformation while at high strain rate deformation,it show the strong effect of strain rate and its flow stress take on vibration due to coexistence of thermal softening and strain-strengthening.The dynamic deformation of TC6 titanium alloy takes the form of localized deformation and the crack often appear in this area.When the crack expands and run through the sample along the localized area,the material tested lose efficacy.The deformation of material is homogeneous at quasi-static deformation,and when the strain reaches to 0.4 approximately,fracture failure of the testing material occurs along direction of the maximum shear stress.