刘娜娜, 陈静波, 郁有祝, 张楠, 苏文辉, 牛永生, 康瑞琴, 刘建平. 岩白菜素咪唑衍生物的合成[J]. 云南大学学报(自然科学版), 2017, 39(2): 278-282. doi: 10.7540/j.ynu.20160418
引用本文: 刘娜娜, 陈静波, 郁有祝, 张楠, 苏文辉, 牛永生, 康瑞琴, 刘建平. 岩白菜素咪唑衍生物的合成[J]. 云南大学学报(自然科学版), 2017, 39(2): 278-282. doi: 10.7540/j.ynu.20160418
shu
LIU Na-na, CHEN Jing-bo, YU You-zhu, ZHANG Nan, SU Wen-Hui, NIU Yong-sheng, KANG Rui-qin, LIU Jian-ping. Synthesis of bergenin imidazole analogs[J]. Journal of Yunnan University: Natural Sciences Edition, 2017, 39(2): 278-282. DOI: 10.7540/j.ynu.20160418
Citation: LIU Na-na, CHEN Jing-bo, YU You-zhu, ZHANG Nan, SU Wen-Hui, NIU Yong-sheng, KANG Rui-qin, LIU Jian-ping. Synthesis of bergenin imidazole analogs[J]. Journal of Yunnan University: Natural Sciences Edition, 2017, 39(2): 278-282. DOI: 10.7540/j.ynu.20160418
shu

岩白菜素咪唑衍生物的合成

Synthesis of bergenin imidazole analogs

    摘要
  • 摘要: 通过对岩白菜素伯羟基的改造,在11位引入了咪唑基团,然后在钯碳氢气条件下脱去酚羟基上的苄基,分别制备了11位咪唑、甲基咪唑、乙基咪唑、苯并咪唑4个结构新颖的岩白菜素衍生物.这些化合物都经1H NMR和13C NMR表征.

     

    Abstract: Imidazole moieties were combined to bergenin through the modification on its primary hydroxyl group at 11 position.Then debenzylation was occurred at the condition of Pd/C and H2 atmosphere.Finally 11-imidazole,11-methyl imidazole,11-ethyl imidazole,11-benzimidazole substituted bergenin derivatives were obtained.And all these 4 new compounds were confirmed by 1H NMR and 13C NMR.

     

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