Abstract: In the presence of catalytic amount of copper salt,an efficient and flexible synthetic method towards the synthesis of a structurally new type of spirocyclic lactams was developed.Their structures were confirmed by 1H NMR,13C NMR,HR-MS and X-ray crystallographic analysis.These compounds were evaluated in vitro against a panel of human tumor cell lines.The results showed that compounds 7a-12 and 7a-13 exhibited higher inhibitory activity selectively against MCF-7 and SW480 cell lines compared with DDP.In particular,compound 7a-16 was more selective to SW-480 cell lines with IC50 values 2.0-fold lower than DDP.