Abstract: Mannich reaction catalyzed by ioaded Iodine use aromatic aldehyde,acetophenone,aniline as starting materials.The effects of catalyst,solvent,reaction time,temperature and quivalency of starting materials on yield were investigated by single factor method.The optimal conditions are:reaction temperature is 25℃,the reaction time is 5 h,the molar ratio of raw materials was 1:1:0.9.The yields range from 85.1% to 98.8% and the product is characterized by IR,NMR and melting point.