Abstract: The wool-loaded BiOBr photocatalyst was prepared using physicochemically treated wool as a carrier. The effect of BiOBr loading on the degradation performance of Rhodamine B was studied, and the stability of the photocatalyst was measured. The result has shown that the pretreated wool could be combined with BiOBr through coordination, and the solid load was stable. At the same time, the coordination restricts the growth of BiOBr particle size. The average particle size of the loaded BiOBr is about 30−50 nm, which provides favorable conditions for efficient catalysis. The degradation performance of the photocatalyst is best when the loading is 30%, and the degradation rate reaches 98.5% at 90 min. The catalyst has high stability, and the degradation rate of Rhodamine B is still 71.5% after repeated use for 5 times. The wool-loaded BiOBr photocatalyst is simple to prepare, the carrier is natural, cheap, non-toxic, which conforms to the concept of green chemistry and has high application value.