Abstract: Various separation techniques such as normal and adverse silica gel and Sephadex LH-20 gel column chramatography were used to investigate the chemical constituents from the leaves of Syzygium brachyantherum. In result, ten compounds, including 3β,23-O-isopropylidenyl-2a,19a-dihydroxy-urs-12-en-28-oic acid (1), hyptaic acid B (2), corosolic acid (3), friedelin (4), friedelan-3β-ol (5), 3β-hydroxy-5-glutinene (6), daucosterol (7), (7R,8S)-3,5'-dimethoxy-4',7-epoxy-8,3'-neolignane-5,9,9'-triol (8), methyl gallate (9) and β-selinene (10) were isolated and determined and their structures were identified by NMR spectroscopic data and comparison with values reported. Among them, compound 1 was a new ketal produced by 2 and acetone during isolation. All compounds were isolated from S. brachyantherum for the first time.