雷泽, 方瑞斌, 朱洪友. 维生素K2(20)的两相合成工艺及其营养剂量对增加骨密度的研究[J]. 云南大学学报(自然科学版), 2011, 33(2): 196-200 .
引用本文: 雷泽, 方瑞斌, 朱洪友. 维生素K2(20)的两相合成工艺及其营养剂量对增加骨密度的研究[J]. 云南大学学报(自然科学版), 2011, 33(2): 196-200 .
shu
LEI Ze, FANG Rui-bin, ZHU Hong-you. The two-phase synthesis of menatetrenone and its dose-effect relationship ofanti-osteoporosis activity in ovariectomized rats[J]. Journal of Yunnan University: Natural Sciences Edition, 2011, 33(2): 196-200 .
Citation: LEI Ze, FANG Rui-bin, ZHU Hong-you. The two-phase synthesis of menatetrenone and its dose-effect relationship ofanti-osteoporosis activity in ovariectomized rats[J]. Journal of Yunnan University: Natural Sciences Edition, 2011, 33(2): 196-200 .
shu

维生素K2(20)的两相合成工艺及其营养剂量对增加骨密度的研究

The two-phase synthesis of menatetrenone and its dose-effect relationship ofanti-osteoporosis activity in ovariectomized rats

    摘要
  • 摘要: 在以BF3·OEt2作催化剂及45~47℃的反应条件下,将大过量的2-甲基-1,4萘二酚循环与香叶基香叶醇(每次保持摩尔比为10:1)在CH3NO2-正己烷两相反应体系中进行Friedel-Crafts烷基化反应合成维生素K2(20)的氢醌,再在催化量的FeCl3·6H2O作用下经空气氧化,以满意的收率及较高的化学选择性合成了维生素K2(20) . 同时,利用去卵巢致大鼠骨质疏松模型,参考维生素K2人体低端推荐摄入量(50μg/d)进行了动物实验剂量设计并进行了维生素K2(20)增加骨密度的营养剂量的量效关系研究,结果表明:每天给药 25~100μg/(kg·d),均能防止去势大鼠的骨流失,使股骨中点及远心端骨密度明显增加(P0.05),并呈现出相应的量效关系.研究为维生素K2(20)的工业生产提供了可能的工艺,也为提高骨密度以预防骨质疏松的人体营养补充剂量(50~100μg/d)提供了可行性依据.

     

    Abstract: With the two-phase reactive system of CH3NO2/n-hexane,the hydroquinone of menatetrenone was prepared at 45—47℃ by BF3·Et2O catalyzed Friedel-Crafts alkylation of 2-methyl-1,4-naphthohydroquinone and gernaylgeraniol.Then menatetrenone was synthesized in good yield and high selectivity by treating the hydroquinone with the catalytic amount of FeCl3·6H2O and the oxygen of air.The dose-effect relationship of anti-osteoporosis activity of menatetrenone in ovariectomized rats was investigated.Our results suggest that low-dose menatetrenone could prevent the bone loss in ovariectomized young rats,thus nutritional dose of menatetrenone may be beneficial in the prevention of osteoporosis in the elderly.

     

    • HTML全文
    • 参考文献(0)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回