冀宪红, 高斌, 朱顺义. 蛇三指环毒素家族的研究进展[J]. 云南大学学报(自然科学版), 2019, 41(5): 1055-1061. doi: 10.7540/j.ynu.20180210
引用本文: 冀宪红, 高斌, 朱顺义. 蛇三指环毒素家族的研究进展[J]. 云南大学学报(自然科学版), 2019, 41(5): 1055-1061. doi: 10.7540/j.ynu.20180210
JI Xian-hong, GAO Bin, ZHU Shun-yi. The research progress of three finger toxin family in snakes[J]. Journal of Yunnan University: Natural Sciences Edition, 2019, 41(5): 1055-1061. DOI: 10.7540/j.ynu.20180210
Citation: JI Xian-hong, GAO Bin, ZHU Shun-yi. The research progress of three finger toxin family in snakes[J]. Journal of Yunnan University: Natural Sciences Edition, 2019, 41(5): 1055-1061. DOI: 10.7540/j.ynu.20180210

蛇三指环毒素家族的研究进展

The research progress of three finger toxin family in snakes

  • 摘要: 蛇毒是其毒腺分泌的,主要由有生物活性的蛋白和多肽等混合物组成. 这些蛋白和多肽大部分可归为两大类:酶类和非酶类. 三指环毒素家族是其中最大的非酶类毒液蛋白类群,虽然该家族的蛋白质都是由β-折叠片组成的三指环结构,但是却呈现出了多样的功能活性. 神经毒素是该家族中很重要的组分. 三指环毒素家族中不同的功能群体结构的差异,导致了其生物功能的多样性以及每个功能类群的特殊性. 蛇的三指环毒素家族很可能起源于无毒的三指环祖先蛋白. 研究表明,正选择在该毒素家族的进化和多样性形成中起重要作用.

     

    Abstract: Snake venom, secreted from the venom glands, is mainly composed of pharmacologically active proteins and polypeptides. That can be divided into enzymatic and components non-enzymatic. The three finger toxin family represents the most abundant types of nonenzymatic snake venom components, and all members share common three fingers structure comprised by β-sheets with diverse functional properties. Neurotoxins are extremely important in the family. Structral variations among different groups of the family may result in functional diversity as well as the uniqueness of each group.The three finger toxin family of snakes has most likely evolved from non-toxic ancestral three-finger scaffold proteins. Researches have demonstrated the receptor variability plays a vital role in driving the evolution and diversification of the venom family.

     

/

返回文章
返回