Abstract:
A series of hybrid imidazole compounds have been prepared from cholesterol,stigmasterol and diosgenin.Their structures were confirmed by 1H NMR,13C NMR,HRMS and IR.These compounds have been evaluated in vitro against a panel of human tumor cell lines.The results showed that 3-benzly-1-(2α-cholest-4-en-3-one)imidazol-3-ium bromide (10) and 3-(3’,4’-methylenedioxy- benzyl) -1-(2α-cholest-4-en-3-one)imidazol-3-ium bromide (13) exhibited higher inhibitory activities against human breast cancer Bcap-37 than cisplatin (DDP).