Abstract: In this paper, the effects of immersion migration experiment on the migration amount of nano zinc oxide in 5% GO-ZnO-PLLA/PLLA (polylactic acid) composite films were quantitatively studied by full immersion method and atomic absorption spectrometry. The effects of different food simulants (acid, oil and water), temperature (30, 45 ℃ and 60 ℃) and immersion time (3, 5, 7 d and 10 d) on the migration content, apparent structure and water vapor permeability of the film were mainly explored. The results showed that different degrees of nano-ZnO particle migration were detected in the three environments. Among them, the migration law of nano-ZnO is as follows: oil environment > acidic environment > water environment. With the extension of temperature and time, the migration increases, resulting in rough surface of fiber membrane and high water vapor permeability. Experimental significance is good.