Abstract: In Wenshan Prefecture, rocky desertification used to be serious, and the ecological environment used to be fragile and sensitive. After years of improvement, a good development trend has appeared. However, multi-source remote sensing is seldom used to carry out its dynamic monitoring in long time series and wide areas. To explore the application potential of domestic satellites in vegetation monitoring, this study combined the advantages of Gaofen-1 satellite (GF-1), Gaofen-5 satellite (GF-5), and Gaofen-6 satellite (GF-6) to invert the vegetative distribution and environment in Wenshan Prefecture from 2013 to 2020. Firstly, the data of GF-5 in the dry season were used for hyperspectral vegetation monitoring, and the data of Advanced Hyperspectral Imager (AHSI) and Visual and Infrared Multispectral Sensor (VIMS) were combined for Remote Sensing Ecological Index (RSEI) analysis. Then, GF-1 and GF-6 were used for time series monitoring through Vegetation Fractional Coverage inversion. The results showed that the average RSEI of the experimental area located at the juncture of the three counties (Yanshan, Guangnan, and Qiubei) was 0.70, indicating that the ecological environment quality was in a relatively good state (from 0.60 to 0.80). The crop stress index and ignitability were high in the west of Yanshan County and the South of Qiubei County, and the forest health index was low in the North of Wenshan City, the Southwest of Qiubei County, and the middle of Yanshan County. From 2013 to 2020, the average vegetation coverage of Wenshan Prefecture was in the range of high vegetation coverage; the proportion of average coverage and highest vegetation coverage area decreased first and then increased.