孙振宇, 陈源思, 张兴杰, 张芮菡, 李宏亮, 肖伟烈, 李晓莉. 鼎湖血桐的酚性成分研究[J]. 云南大学学报(自然科学版), 2022, 44(6): 1265-1271. doi: 10.7540/j.ynu.20220018
引用本文: 孙振宇, 陈源思, 张兴杰, 张芮菡, 李宏亮, 肖伟烈, 李晓莉. 鼎湖血桐的酚性成分研究[J]. 云南大学学报(自然科学版), 2022, 44(6): 1265-1271. doi: 10.7540/j.ynu.20220018
SUN Zhen-yu, CHEN Yuan-si, ZHANG Xing-jie, ZHANG Rui-han, LI Hong-liang, XIAO Wei-lie, LI Xiao-li. Phenolic constituents from Macaranga Dampsonii[J]. Journal of Yunnan University: Natural Sciences Edition, 2022, 44(6): 1265-1271. DOI: 10.7540/j.ynu.20220018
Citation: SUN Zhen-yu, CHEN Yuan-si, ZHANG Xing-jie, ZHANG Rui-han, LI Hong-liang, XIAO Wei-lie, LI Xiao-li. Phenolic constituents from Macaranga Dampsonii[J]. Journal of Yunnan University: Natural Sciences Edition, 2022, 44(6): 1265-1271. DOI: 10.7540/j.ynu.20220018

鼎湖血桐的酚性成分研究

Phenolic constituents from Macaranga Dampsonii

  • 摘要: 通过分析−半制备型HPLC和柱色谱法对鼎湖血桐枝叶的化学成分进行了分离纯化,运用NMR技术对化合物结构进行了鉴定,得到了13个单体化学成分,分别为香叶木素( 1 ),蜜橘素( 2 ),川陈皮素( 3 ),5,4′-二羟基-3,6,7-三甲氧基黄酮( 4 ),猫眼草酚D( 5 ),甘草苷元( 6 ),表儿茶素( 7 ),儿茶素( 8 ),异甘草苷元( 9 ),根皮素( 10 ),根皮苷( 11 ),反式白藜芦醇-3-O-β-D-吡喃葡萄糖苷( 12 )和厚朴酚( 13 ),所有化合物均为首次从该植物中分离得到. 化合物 4和13 对MCF-7 和HCT-116肿瘤细胞株表现出一定的细胞毒活性.

     

    Abstract: The chemical constituents from Macaranga sampsonii were isolated and purified by semi-preparative high performance liquid chromatography, column chromatography on silica gel, Sephadex LH-20 and HPLC. The structures of the compounds were elucidated by NMR spectral analysis. Thirteen compounds were isolated and identified, including diosmetin (1), tangeretin (2) , nobiletin (3) , 5,4'-dihydroxy-3,6,7-trimethoxyflavone (4) , chrysosplenol D (5) , liquiritigenin (6) , epicatechin (7) , catechin (8) , isoliquiritigenin (9) , phloretin (10) , phloridzin (11) , trans-resveratrol-3-O-β-D-glucopyranoside (12) , magnolol (13) . All these compounds were first isolated from this plant. And compounds 4 and 13 showed weak anti-tumor activity.

     

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