Abstract:
The chemical constituents from
Macaranga sampsonii were isolated and purified by semi-preparative high performance liquid chromatography, column chromatography on silica gel, Sephadex LH-20 and HPLC. The structures of the compounds were elucidated by NMR spectral analysis. Thirteen compounds were isolated and identified, including diosmetin
(1), tangeretin
(2) , nobiletin
(3) , 5,4'-dihydroxy-3,6,7-trimethoxyflavone
(4) , chrysosplenol D
(5) , liquiritigenin
(6) , epicatechin
(7) , catechin
(8) , isoliquiritigenin
(9) , phloretin
(10) , phloridzin
(11) , trans-resveratrol-3-O-
β-D-glucopyranoside
(12) , magnolol
(13) . All these compounds were first isolated from this plant
. And compounds
4 and
13 showed weak anti-tumor activity.