周献冬, 林亲雄, 杨新洲. 贵州金丝桃的化学成分研究[J]. 云南大学学报(自然科学版), 2022, 44(6): 1272-1279. doi: 10.7540/j.ynu.20220024
引用本文: 周献冬, 林亲雄, 杨新洲. 贵州金丝桃的化学成分研究[J]. 云南大学学报(自然科学版), 2022, 44(6): 1272-1279. doi: 10.7540/j.ynu.20220024
ZHOU Xian-dong, LIN Qin-xiong, YANG Xin-zhou. Study on chemical components of Hypericum kouytchense Lévl[J]. Journal of Yunnan University: Natural Sciences Edition, 2022, 44(6): 1272-1279. DOI: 10.7540/j.ynu.20220024
Citation: ZHOU Xian-dong, LIN Qin-xiong, YANG Xin-zhou. Study on chemical components of Hypericum kouytchense Lévl[J]. Journal of Yunnan University: Natural Sciences Edition, 2022, 44(6): 1272-1279. DOI: 10.7540/j.ynu.20220024

贵州金丝桃的化学成分研究

Study on chemical components of Hypericum kouytchense Lévl

  • 摘要: 综合应用正相硅胶柱层析、HP-20大孔树脂柱层析、Sephadex LH-20凝胶柱色谱、半制备HPLC等多种分离手段对贵州金丝桃(Hypericum kouytchense Lévl)乙酸乙酯部位进行分离纯化,从贵州金丝桃乙酸乙酯部位提取物中分离得到了17个化合物,运用NMR、MS等现代波谱方法分别鉴定为无羁萜( 1 )、白桦脂酸( 2 )、3,4-二羟基-2-甲氧基氧杂蒽酮( 3 )、1,3-二羟基-2-甲氧基氧杂蒽酮( 4 )、1,3-二羟基-5-甲氧基氧杂蒽酮( 5 )、1,5-二羟基-6,7-二甲氧基氧杂蒽酮( 6 )、2,3-二甲氧基氧杂蒽酮( 7 )、cadensin D( 8 )、subalatin( 9 )、kielcorin( 10 )、异巴西红厚壳素( 11 )、toxyloxanthone B( 12 )、2-deprenylrheediaxanthone B( 13 )、1,7-二羟基氧杂蒽酮( 14 )、3-羟基-1,4,7-三甲氧基二苯并呋喃( 15 )、咖啡酸乙酯( 16 )和苯甲酸( 17 ). 其中化合物 1131517 为首次从该植物中分离得到.

     

    Abstract: The chemical constituents of the ethyl acetate fraction of Hypericum kouytchense Lévl were isolated and purified by silica gel column chromatography (CC), HP-20 macroporous resin CC, Sephadex LH-20 CC, semipreparative high performance liquid chromatography, and other separation methods. Seventeen compounds were isolated from the ethyl acetate fraction of H. kouytchense. By using NMR, MS, and other modern spectral techniques, the structures of the compounds were identified as friedelin ( 1 ), betulinic acid ( 2 ), 3,4-dihydroxy-2-methoxy-xanthone ( 3 ), 1,3-dihydroxy-2-methoxy-xanthone ( 4 ), 1,3-dihydroxy-5-methoxy-xanthone ( 5 ), 1,5-dihydroxy-6,7-dimethoxyxanthone ( 6 ), 2,3-dimethoxyxanthone ( 7 ), cadensin D ( 8 ), subalatin ( 9) , kielcorin ( 10 ), isojacareubin ( 11 ), toxyloxanthone B ( 12 ), 2-deprenylrheediaxanthone B ( 13 ), 1,7-dihydroxyxanthone ( 14 ), 3-hydroxy-1,4,7-trimethoxydibenzofuran ( 15 ), ethyl caffeate ( 16 ), and benzoic acid ( 17 ). Compounds 1-13 and compounds 15-17 were isolated from H. kouytchense for the first time.

     

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