Abstract: Four cinchona-derived chiral phase transfer catalysts were synthesized to catalytic asymmetric Mannich reaction of dimethyl (2-oxopropyl)phosphonate with α-aminosulfones to prepare β-aminophosphonates. After the optimization of the reaction conditions, the optimal reaction conditions were determined at −40 ℃, using compound D as the catalyst, toluene as the solvent, and 6% LiOH water solvent as the base, and the yield of chiral β-aminophosphonate derivatives reached 90%, the ee reached 60%.