Abstract: By using daily temperature and precipitation station data of Guizhou and the NCEP reanalysis data and the synthetic analysis methods, the persistent wet-cold anomalous events in winter in Guizhou in are investigated. The results show that: (1) The central and western part of Guizhou is the single-station high-frequency area, and altitude is one of the influencing factors for the frequency of wet-cold anomalous events. The average duration of regional persistent cold-wet anomalies is 7.3 d, mostly occurring in January. The precipitation anomalies of the precipitation-heavy events are significantly larger than that of the precipitation-poor type events, and the temperature anomalies of both types of events are centered in the central southern parts of Guizhou. (2) The 500 hPa circulation of the precipitation-heavy type events is "double obstruction type", which is influenced by the ridges of the Ural Mountains-Polar Region and Okhotsk. The location of the ridge for the low precipitation events is more easterly, influenced by the eastward shift of the Nordic-New Guinea ridge. The Mongolian high anomaly associated with the precipitation-heavy events is stronger and more extensive than that of the precipitation-heavy events, and produces stronger cooling. The paths of cold air for the precipitation-heavy events are predominantly northerly, whereas the that of the precipitation-poor events are predominantly westerly. (3) At 700 hPa, there is a significant southwesterly wind anomaly transporting warm and humid air to provide water vapor conditions for precipitation in the Guizhou region for the precipitation-heavy events, while the westerly winds dominate the precipitation-poor events. The water vapor of the precipitation-heavy events from the Bay of Bengal and the South China Sea, and there is water vapor convergence in both the 700 hPa and 850 hPa. While that of the precipitation-poor events are only from the South China Sea, and the water vapor convergence only exists at 850 hPa and is relatively weak.