Abstract: A series of Cu/Mg/Al based catalysts were prepared by calcination of the Cu/Mg/Al hydrotalcite precursor which was synthesized by the co-precipitation method with the same Cu/Mg/Al molar ratio of 15∶60∶25 at various temperatures.The catalysts were characterized by XRD,TG/DTG,BET,H2-TPR and FT-IR to explore the effect of calcination temperature on the transfer hydrogenation liquefaction of cellulose over Cu/Mg/Al catalysts.The results showed that Cu/Mg/Al hydrotalcite was almost completely decomposed at 450 ℃.It has a good stability because of the proper force between CuO and MgO and an excellent catalytic activity because of the uniformity of CuO at such a temperature.Poor crystallization and stability were the reasons which lead to the decrease of the catalyst activity when the calcination temperature is less than 450 ℃. Higher calcination temperature (450 ℃) resulted in the agglomeration of CuO.MgAl2O4 which produced at high calcination temperature(≥650 ℃) and played a role in separating CuO decomposed in the high temperature and pressure reaction of liquefaction of cellulose,thus causing a second agglomeration.High calcination temperature also resulted in the sintering of metal oxides,thereby decreasing the catalyst activity.