Abstract: Fifteen novel indane-imidazole derivatives were prepared and evaluated in vitro against a panel of human tumor cell lines and bacterial activities.The results showed that the compounds 7,15,16 and 18 were found to have the most potent antitumor activities.In particular,compound 15 was found to be the most potent derivative and exhibited cytotoxic activity selectively against HL-60,SMMC-7721 and A-549 cell lines more sensitive to DDP.Compounds 7,10,14,15,16 and 17 have better antibacterial activity against S.aureus and B.subtilis,as well as compound 8 displayed selectively against S.aureus.