Abstract: With the SARS-CoV-2 main protease (M^pro) and RNA-dependent RNA polymerase (RdRp) as targets, phenanthridine-type compounds for discoverying potential inhibitor on viral replication were designed and screened. Using open source software of molecular docking Autodock vina and molecular visualization system Pymol 2.1.0, the designing and virtual screening of phenanthridine-type ligand library were established. Hit compound to analyze binding mode and structure-activity relationship was extracted. Results show that specific phenanthridine derivatives can strongly bind to M^pro and RdRp respectively. It indicates the phenanthridine derivatives with rational design have great potential against SARS-CoV-2.