麻楝枝叶中的5个non-phragmalin柠檬苦素类化合物

Five non-phragmalin limonoid compounds from twigs and leaves of Chukrasia tabularis

  • 摘要: 对麻楝(Chukrasia tabularis)的枝叶部位的化学成分进行研究,以期发现具新颖结构的化学成分;方法:对麻楝枝叶的95%甲醇提取物进行萃取,得到的石油醚萃取部分反复运用大孔树脂、正向硅胶柱层析、反相RP-18柱层析及高效液相色谱等色谱方法进行分离纯化,获得的化合物以核磁共振波谱和质谱结合文献进行鉴定;从麻楝的枝叶部分分离获得了5个化合物,分别为:6-deoxy-9-hydroxycedrodorin(Ⅰ),xyloccensin K(Ⅱ), methyl 8-hydroxy-8,30-dihydroangolensate(Ⅲ),sapelin E acetate(Ⅳ),16-dehydroxy-23-hydroxymeliasenin F(Ⅴ);5个化合物均是从该属植物中首次分离得到的化合物.

     

    Abstract: In order to seek for novel compounds from Chukrasia tabularis,twigs and leaves of C.tabularis were extracted with 95% methanol,which was then suspended in water and extracted with petroleum ether,EtOAc,successively.The petroleum ether part was extensively separated over a whole series of silica gel,macroporous resin,RP-18 and HPLC to afford five compounds.These compounds were elucidated by extensive analyses of spectroscopic analysis(MS,NMR,etc.) and were finally determined as 6-deoxy-9-hydroxycedrodorin(I),xyloccensin K(Ⅱ),methyl 8-hydroxy-8,30-dihydro-angolensate(Ⅲ),sapelin E acetate(IV),16-dehydroxy-23-hydroxymeliasenin F(V),which were all isolated from genus Chukrasia for the first time.

     

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