Abstract: According to the mean-field theory and nonlinear theory,the dynamic behavior of SIRSmodel with immunization on regular lattice is discussed in detail.The effects of artificial immunization,crowd density and the moving activity of individuals on disease spreading are investigated by computer simulation.The results indicate that artificial immunization can reduce the stable infective ratio and increase the threshold of epidemic spread.Furthermore,its effect in the case of static crowd is better than that of moving crowd.On the contrary,the moving activity of individuals can enhance the stable infective ratio and decrease the threshold of epidemic spread.